Predicting difficult-to-treat chronic rhinosinusitis by noninvasive biological markers

Non-pharmacological biological treatment approaches to difficult-to-treat depression.

There has been substantial recent interest in novel brain stimulation treatments for difficult-to-treat depression. Electroconvulsive therapy (ECT) is a well established, effective treatment for severe depression. ECT's problematic side-effect profile and questions regarding optimal administration methods continue to be investigated. Magnetic seizure therapy, although very early in development,...

309 Difficult-to-treat Asthma with Idiopathic Chronic Eosinophilic Pneumonia

309 Difficult-to-treat Asthma with Idiopathic Chronic Eosinophilic Pneumonia Norbert Pauk, PhD, MD. Department of Pneumology, Faculty Hospital Na Bulovce, 3rd Faculty of Charles University, Prague, Czech Republic. Background: Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare disorder of unknown cause characterised by subacute or chronic respiratory and general symptoms, alveolar and /o...

Managing chronic hepatitis C in the difficult-to-treat patient

Patients with chronic hepatitis C virus (HCV) infection and disease-related complications - among them cirrhosis and liver failure - pose a particular management challenge. Some of these patients may fail to respond to current therapy (non-responders), and some are affected so severely that treatment puts them at an unacceptable risk for complications. Treatment with pegylated interferon (peg-I...

difficult-to-treat, life-threatening cytomegalovirus pneumonia in a patient with chronic renal disease

Adenomyosis: Difficult to Diagnose, and Difficult to Treat

Drug therapy may be effective in controlling symptoms but the frequent coexistence of endometriosis and the lack of controlled studies make their efficacy difficult to quantify. Danazol IUD has been shown to reduce symptoms. Conservative surgery involving endomyometrial ablation, laparoscopic myometrial electrocoagulation or excision has proven to be effective in more than 50% of patients, alth...